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Host–Bacterial Symbiosis in Health and Disease Janet Chow 1 , S. Melanie Lee 1 , Yue Shen 1 , Arya Khosravi 1 , and Sarkis K. Mazmanian Division of Biology, California Institute of Technology, Pasadena, California, USA Abstract All animals live in symbiosis. Shaped by eons of co-evolution, host-bacterial associations have developed into prosperous relationships creating mechanisms for mutual benefits to both microbe and host. No better example exists in biology than the astounding numbers of bacteria harbored by
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